Abstract #3910
Monitoring of endothelial permeability and plaque progression in a rabbit model of atherothrombosis using an albumin-binding MR contrast agent
Alkystis Phinikaridou 1 , Marcelo K Andia 2 , Prakash Saha 1 , Alberto Smith 1 , and Rene M Botnar 1
1
King's College London, London, United
Kingdom,
2
Pontificia
Universidad Catolica de Chile, Santiago, Chile
Endothelial dysfunction, characterized by increased
vascular permeability and impaired endothelial-dependent
vasodilation, precedes and portends the development of
atherosclerosis. MRI studies have shown that impaired
focal endothelial dysfunction correlates with the extent
of focal plaque burden in the coronary arteries. We have
also reported that gadofosveset, an albumin-binding MR
contrast agent, can be used to non-invasively assess
endothelial permeability, plaque burden progression and
regression in a murine model of accelerated
atherosclerosis. To expand our previous findings we
investigated the interplay between endothelial
dysfunction, plaque progression and instability in a
bigger animal (rabbit) model of accelerated disease.
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