Abstract #4031
Intratracheal administration of ultra-small Gd-based nanoparticles: a new protocol for brain tumor targeting
Andrea Bianchi 1 , Damien Moncelet 1 , Franois Lux 2 , Emeline Julie Ribot 1 , Nawal Tassali 1 , Veronique Bouchaud 1 , Olivier Tillement 2 , Pierre Voisin 1 , and Yannick Crmillieux 1
1
Centre de Rsonance Magntique des Systmes
Biologiques, Universit Bordeaux Segalen, Bordeaux,
Bordeaux, France,
2
Institut
Lumire Matire, Universit Claude Bernard, Lyon, France
Glioblastoma is the most aggressive, common and lethal
brain tumor. In this context, new noninvasive methods
for early detection and therapy are needed in order to
improve the prognosis of this pathology. We present here
an in vivo MRI longitudinal study of brain cancer
detection in tumor-bearing immunodeficient mice through
intratracheally- and intravenously- administered
multimodal Ultra-Small Rigid Platforms. In this study we
showed for the first time that the synergic employment
of a strongly T1-weighted MRI UTE sequence and
intratracheally-administered gadolinium-based
nanoparticles allow the high-precision detection of
brain tumor and of its contours.
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