Abstract #4032
Monitoring of glioblastoma response to a dual PI3K/mTOR inhibitor using hyperpolarized 13C MRSI and 1H MRS
Marina Radoul 1 , Myriam M Chaumeil 1 , Pia Eriksson 1 , Jose L Izquierdo Garcia 1 , and Sabrina M Ronen 1
1
Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States
PI3K/Akt/mTOR, one of the important signaling pathways,
is activated in ~88% of GBM and different steps in this
pathway can serve as therapeutic targets. This study
demonstrates non-invasive monitoring of metabolic
response to treatment with XL765/SAR245409, a novel dual
PI3K/mTOR inhibitor. The inhibition in PI3K/Akt/mTOR
signaling pathway leads to changes in levels of 13C MRS-detectable
hyperpolarized lactate production from pyruvate and
levels of 1H MRS-detectable total choline. Importantly,
metabolic changes are associated with significantly
longer survival in the case of XL765/SAR245409-treated
animals, independent of tumor size.
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