Poly(I:C) Treatment in a Spontaneous Hepatocellular Carcinoma Mouse Model
Jeffrey David Steinberg 1 , Justin Lee 2 , Philipp Kaldis 3 , Jean-Pierre Abastado 2,4 , and Valerie Chew 2
Singapore Bioimaging Consortium, Agency for
Science, Technology and Research, Singapore, Singapore,
Immunology Network, Agency for Science, Technology and
Research, Singapore, Singapore,
of Molecular and Cell Biology, Agency for Science,
Technology and Research, Singapore, Singapore,
de Recherches Internationales Servier, Suresnes, France
Hepatocellular carcinoma (HCC) is the 6th most common
cancer with the 3rd highest mortality worldwide.
Prognosis for HCC is generally poor with a 5-year
survival rate of only 15%. In this study a spontaneous
HCC mouse model was treated using poly(I:C), a synthetic
TLR3 ligand that activates NK cells and is cytotoxic to
HCC cells. Using a 3D T1-weighted MPRAGE MRI sequence,
the tumor progression could be monitored. Average tumor
growth was 8 times and 183 times the pre-therapy tumor
volume for the treatment and control mice respectively.
Thus, poly(I:C) was effective in delaying HCC tumor
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