Extracellular sodium MRI, a non-invasive endogenous marker for tumoral response to photodynamic therapy associated with nitroglycerin.
Carole D. Thomas 1,2 , Florent Poyer 1,2 , Philippe Maillard 1,3 , Mihaela Lupu 1,2 , and Joel Mispelter 1,2
Institut Curie, Orsay, France,
U759, Orsay, France,
UMR176, Orsay, France
The aim of this study was double. Firstly, to determine
if photodynamic therapy associated with nitroglycerin
ointment was able to induce a major cellular death on a
tumoral line of retinoblastoma that was less responsive
to treatment. Secondly to determine if extracellular MRI
follow-up is able to give rapid information about tumor
cells destruction. Nitroglycerin increased the
photosensitzer concentration at the tumor level and
hence the treatment efficiency. Sodium MRI monitored
non-invasively the cellular destruction, showing a local
increase of sodium concentration specific to
extracellular sodium amount all over where cells were
irreversible damaged by PDT.
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