Abstract #4052
Magnetic resonance metabolic profiling of breast cancer tissue obtained with core needle biopsy for predicting pathologic response to neoadjuvant chemotherapy
Ji Soo Choi 1 , Hyeon-Man Baek 2 , Suhkmann Kim 3 , Min Jung Kim 4 , Hee Jung Moon 4 , and Eun-Kyung Kim 4
1
Samsung Medical Center, Seoul, Seoul, Korea,
2
Korea
Basic Science Institute, Chungbuk, Korea,
3
Pusan
National University, Busan, Korea,
4
Yonsei
University College of Medicine, Seoul, Korea
We performed metabolic profiling of 37 core needle
biopsy samples collected from locally advanced breast
cancer before neoadjuvant chemotherapy (NAC) using
HR-MAS MRS. Various metabolites including choline-containing
compounds were identified and quantified by HR-MAS MRS
in all tissue samples. In multivariate analysis, the
OPLS-DA models built with HR-MAS MR metabolic profiles
showed visible discrimination between the pathologic
response groups. This study showed OPLS-DA multivariate
analysis using metabolic profiles of pretreatment CNB
samples assessed by HR- MAS MRS may be used to predict
pathologic response before NAC.
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