Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma: comparison with invasive carcinoma of no special type
Natsuko Onishi 1 , Shotaro Kanao 1 , Masako Kataoka 1 , Mami Iima 1 , Rena Sakaguchi 1 , Makiko Kawai 1 , Tatsuki Kataoka 2 , Yoshiki Mikami 2 , Masakazu Toi 3 , and Kaori Togashi 1
Department of Diagnostic Imaging and Nuclear
Medicine, Kyoto Univerisity Graduate School of Medicine,
Kyoto, Kyoto, Japan,
of Diagnostic Pathology, Kyoto Univerisity Graduate
School of Medicine, Kyoto, Kyoto, Japan,
of Breast Surgery, Kyoto Univerisity Graduate School of
Medicine, Kyoto, Kyoto, Japan
ADC is known to have inverse correlation with
cellularity. Considering that cellularity is linked with
prognosis in breast mucinous carcinoma (MBC), we
examined the association between ADC and Ki-67 index (a
marker of tumor proliferation) in MBC comparing with
invasive carcinoma of no special type. ADC showed
inverse correlation with cellularity(r=-0.802,
p=<0.0001) and with Ki-67 index (r=-0.825, p=<0.0001) in
MBC. The ability of ADC to classify highly proliferating
MBC from low proliferating one was also demonstrated.
ADC can be a promising non-invasive surrogate marker for
Ki-67 index in the risk stratification of MBC.
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