Abstract #4054
High-Resolution Metabolic Imaging of Human Breast Cancer
Charles S Springer, Jr. 1 , Xin Li 1 , Luminita A. Tudorica 2 , Karen Y. Oh 2 , Nicole Roy 2 , Stephen Y-C. Chui 3 , Arpana M. Naik 4 , Megan L. Holtorf 5 , Aneela Afzal 1 , William D. Rooney 1 , and Wei Huang 1
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Diagnostic
Radiology, Oregon Health & Science University, Portland,
Oregon, United States,
3
Hematology/Oncology,
Oregon Health & Science University, Portland, Oregon,
United States,
4
Surgical
Oncology, Oregon Health & Science University, Portland,
Oregon, United States,
5
Clinical
Trials Office, Oregon Health & Science University,
Portland, Oregon, United States
Tumors exhibit metabolic heterogeneity. This requires
individualized metabolic imaging with intra-tumor
resolution. Shutter-speed pharmacokinetic analyses of
DCE-MRI data provide tau
i
, the mean
intracellular water lifetime, with high-resolution. We
present results for human breast cancer
in
vivo
. Comparison of tau
i
heterogeneity
with that of other biomarkers and in response to therapy
shows that tau
i
is
inversely related to on-going Na
+
/K
+
ATPase
activity.
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