Water Unsuppressed 1H MR Spectroscopic Imaging Of The Prostate

Proton MR spectroscopic imaging is commonly performed with water signal suppression to avoid artifacts from side bands of the large water signal, but this signal can be very useful for estimating metabolite concentrations by providing a line-shape reference and a quantification of the water signal. In this study we developed water unsuppressed 3D MRSI of the prostate and used it to provide choline concentration maps for localization of prostate cancer. We observed that high choline concentrations co-localised to tumour foci as confirmed on histopathological staining of radical prostatectomy specimens.

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