Detection and grading of prostate cancer using model-based spectral fitting
Gregory J. Metzger 1 , Benjamin Fossen 1 , Patrick J. Bolan 1 , Chrisopher Warlick 2 , Badrinath Konety 2 , Stephen C. Schmechel 3 , Chaitanya Kalavagunta 1 , and Ivan Tkac 1
Center for Magnetic Resonance Research,
University of Minnesota, Minneapolis, MN, United States,
Surgery, University of Minnesota, Minneapolis, MN,
Medicine, University of Washington, WA, United States
Model-based fitting of prostate spectra can produce more
selective metabolite ratios than conventional peak
integration. The model-based ratio tCho/Cit was found to
have a strong correlation with cancer aggressiveness
(grade), comparable with the standard approach of
CSC/Cit ratio, but with the advantage of greater
potential selectivity at higher fields.
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