Abstract #4177
CONTINUOUS THETA-BURST STIMULATION INDUCES CHANGES IN FUNCTIONAL CONNECTIVITY DURING REST
Chiara Mastropasqua 1,2 , Marco Bozzali 1 , Mara Cercignani 1,3 , Viviana Ponzo 4 , and Giacomo Koch 4
1
Neuroimaging Laboratory, IRCCS Santa Lucia,
Rome, Italy,
2
Trieste
University, Trieste, Italy, Italy,
3
Clinical
Imaging Sciences Centre - University of Sussex, Brighton
and Sussex Medical School, Brighton, United Kingdom,
4
Department
of Clinical and Behavioural Neurology, IRCCS Santa
Lucia, Rome, Italy
Our aim was to combine transcranial-magnetic stimulation
and resting-state (RS) fMRI to investigate changes in
functional connectivity at rest induced by prefrontal
continuous theta-burst stimulation (cTBS). Seed-based
analysis was used to identify the main connections to
the prefrontal cortex. The adjacency matrix summarising
the correlation between the resulting 29 regions was
computed before and after cTBS, and compared using the
Network Based Statistics toolbox. After cTBS,
thecorrelation between the right prefrontal cortex and
right parietal cortex was decreased, demonstrating for
the firts time the possibility to induce selective
changes in a specific region without interfering with
functionally correlated area.
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