Abstract #4490
Experimentally estimated non-Gaussian water diffusion at a large range of b-values
Louise Munk Rydtoft 1 , Brian Hansen 1 , Mikkel Bo Hansen 1 , and Sune Nrhj Jespersen 1,2
1
CFIN / MindLab, Aarhus university, Aarhus,
Denmark,
2
Department
of physics and astronomy, Aarhus University, Denmark
Conventionally DTI is deemed accurate for b-values below
1000 s/mm
2
and
DKI for b-values below 2000 s/mm
2
. By
analysing DKI and DTI fits on data from a human
volunteer and perfusion fixated rat, we show the DKI
model is a better fit for a linearly increasing ratio of
voxels, independent on tissue type. Up to one-third of
voxels are better fitted by DKI when maximum b-value is
1000 s/mm
2
. DKI is a convincing alternative
to DTI, even at smaller b-values that has generally been
accepted. Also, we show that the fixation process indeed
restricts diffusion; this is disputed in the literature.
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