Abstract #4718
Transverse Relaxation and Volumetric Neural Changes in the H67D HFE High Iron Mouse Model
Mark David Meadowcroft 1,2 , Douglas G Peters 1 , Carson Purnell 2 , Fatima Ali-Rahmani 1 , Qing X Yang 1,2 , and James R Connor 1
1
Neurosurgery, The Pennsylvania State
University - College of Medicine, Hershey, PA, United
States,
2
Radiology,
The Pennsylvania State University - College of Medicine,
Hershey, PA, United States
High Iron (HFE) H63D and C282Y polymorphisms are found
with increased prevalence in numerous neurodegenerative
diseases. A mouse model has been generated that has a
knock-in of the mouse homolog (H67D) for the human HFE
gene. This mouse model has been shown to have
alterations in brain iron homeostasis and promotes an
environment of oxidative stress. The goal of this study
is to longitudinally track the H67D mouse brain changes
with non-invasive imaging parametric imaging. The
results show that the H67D mice have alterations in
transverse relaxation indicative of high iron loading
and changes in volumetric congruent with neuronal
atrophy.
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