Assessment of cortical phase changes in Alzheimers disease patients at 3T using T2*-weighted imaging.
Sanneke van Rooden 1 , Naomi Smulders 1 , Maarten J. Versluis 1 , Annemarieke M. van Opstal 1 , Andrew G. Webb 1 , Mark A. van Buchem 1 , and Jeroen van der Grond 1
Radiology, Leiden University Medical Center,
Leiden, Zuid-Holland, Netherlands
Recent findings suggested that the level of iron
accumulation, which may reflect AD pathology and more
specifically amyloid deposition, is reflected by phase
information on T2*-weighted MRI at 7T. The aim of this
study was to translate the imaging methods from 7T to 3T
MRI to investigate whether these differences could be
detected using T2*-weighted 3T MRI data. Our 3T MRI data
show no phase differences between AD patients and
controls as opposed to our previous 7T MRI data which
showed an increased cortical phase shifts in AD
patients, and an association with cognitive performance.
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