Abstract #4771
Time dependent treatment outcomes of NBO in experimental ischemic stroke
Yash Vardhan Tiwari 1 , Pavel Rodriguez 1 , Yuhao Sun 1 , Zhao Jiang 1 , Fang Du 1 , Qiang Shen 1 , Wei Li 1 , and Timothy Q Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center San Antonio, San Antonio,
Texas, United States
Previous studies have shown normobaric hyperoxia (NBO)
to be effective in extending treatment time window in
animal model of transient cerebral ischemia. However,
both positive and negative effects of NBO treatment have
been reported. As such, it is highly likely that the
efficacy of NBO treatment in the early phase of ischemic
insult is critically dependent on the treatment
duration. To test this hypothesis, we evaluated the
effects of varying treatment duration for NBO
administration (25 and 150 min) on the 60-min MCAO model
of stroke, longitudinally and noninvasively using
quantitative MRI. We found that in early phase of acute
experimental stroke the treatment outcome of NBO varies
in a time dependent manner.
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