Possible Contribution of the Extracellular Matrix to the MRI Contrast in the Brain
Riccardo Metere 1 , Markus Morawski 2 , Henrik Marschner 1 , Carsten Jger 2 , Tobias Streubel 1 , Stefan Geyer 1 , Katja Reimann 1 , Andreas Schfer 1 , and Harald E. Mller 1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Germany,
for Brain Research, University of Leipzig, Leipzig,
The tissue composition of the brain can be related to
different contrast sources in quantitative MRI imaging.
Particularly, myelin and iron are considered to be the
major source of MRI contrast, with strong correlation to
, respectively. However, other
components, and particularly the relatively abundant
extracellular matrix, may play a role in the generation
of MRI contrast. In this work we present preliminary
experiments showing a contrast change in quantitative
relaxation maps of a brain tissue sample before and
after the digestion of the extracellular matrix, thus
supporting the hypothesis that this componet contributes
to MRI contrast.
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