Signatures of microstructure in conventional gradient and spin echo signals
Pippa Storey 1 , Sohae Chung 1 , Noam Ben-Eliezer 1 , Gregory Lemberskiy 1 , Yvonne W. Lui 1 , and Dmitry S. Novikov 1
Radiology Department, New York University
School of Medicine, New York, NY, United States
Diffusion imaging has long been the method of choice for
probing tissue microstructure. We show that signatures
of microstructure are also present in the signals from
conventional gradient and spin echo sequences.
Preliminary results from phantoms containing polystyrene
beads of known diameter demonstrate that the logarithms
of the signals from both multiple gradient echo and
single spin echo sequences decrease nonlinearly with TE,
in agreement with theory. Numerical fits provide
estimates of bead diameter and magnetic susceptibility
in rough agreement with expected values. This has
implications for studies of tissue microstructure and
for interpretation of gradient and spin echo signals.
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