Abstract #0015
Dependance of the apparent T 1 on Magetization Transfer
Peter van Gelderen 1 , Xu Jiang 1 , and Jeff H Duyn 1
1
AMRI, LFMI, NINDS, National Institutes of
Health, Bethesda, MD, United States
In human brain, T1-contrast is strongly affected by
bound protons in myelin, whose rapid T1-relaxation
influences the more mobile water protons through
magnetization transfer. MT also affects the apparent,
instantaneous T1-relaxation in inversion recovery (IR)
experiments due to magnetization differences between
bound and mobile protons generated by the inversion
pulse. The amplitude and timescale of this effect was
investigated comparing the IR following inversions at
different B1-levels, which differentially saturate the
bound proton magnetization. The white-matter IR
resembled a two- exponential decay, with the more rapid
decay having a 90ms time constant and a B1-dependent
amplitude ranging from 12-19%.
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