Abstract #0091
Hyperpolarized [1- 13 C]octanoate: a probe of myocardial -oxidation
Hikari A. I. Yoshihara 1,2 , Jessica A. M. Bastiaansen 2,3 , Magnus Karlsson 4 , Mathilde Lerche 4 , Arnaud Comment 2,5 , and Juerg Schwitter 1
1
Division of Cardiology and Cardiac MR
Center, Lausanne University Hospital, Lausanne,
Switzerland,
2
Center
for Biomedical Imaging (CIBM), Lausanne, Switzerland,
3
Department
of Radiology, Lausanne University Hospital and
University of Lausanne, Switzerland,
4
Albeda
Research ApS, Copenhagen, Denmark,
5
Institute
of Physics of Biological Systems, Ecole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland
The heart is fueled mainly by long-chain fatty acids. We
report the in vivo myocardial metabolism of
hyperpolarized [1-
13
C]octanoate, a
medium-chain fatty acid. The hyperpolarized signal is
short-lived in the blood, but a metabolite signal from
[1-
13
C]acetylcarnitine was observed,
indicating the uptake of octanoate into the mitochondria
and its
-oxidation
to acetyl-CoA. Additional metabolite signals from [5-
13
C]glutamate,
[5-
13
C]citrate and [1-
13
C]acetoacetate
were occasionally observed. The acetylcarnitine signal
relative to octanoate tended to be lower and more
variable in fasted versus fed rats. This study
demonstrates that hyperpolarized
13
C-labeled
medium-chain fatty acids can be used as metabolic probes
in the heart.
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