Abstract #0091

Hyperpolarized [1- 13 C]octanoate: a probe of myocardial -oxidation

Hikari A. I. Yoshihara ^1,2 , Jessica A. M. Bastiaansen ^2,3 , Magnus Karlsson ⁴ , Mathilde Lerche ⁴ , Arnaud Comment ^2,5 , and Juerg Schwitter ¹

¹ Division of Cardiology and Cardiac MR Center, Lausanne University Hospital, Lausanne, Switzerland, ² Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, ³ Department of Radiology, Lausanne University Hospital and University of Lausanne, Switzerland, ⁴ Albeda Research ApS, Copenhagen, Denmark, ⁵ Institute of Physics of Biological Systems, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

The heart is fueled mainly by long-chain fatty acids. We report the in vivo myocardial metabolism of hyperpolarized [1- ¹³ C]octanoate, a medium-chain fatty acid. The hyperpolarized signal is short-lived in the blood, but a metabolite signal from [1- ¹³ C]acetylcarnitine was observed, indicating the uptake of octanoate into the mitochondria and its lower case Greek beta

-oxidation to acetyl-CoA. Additional metabolite signals from [5- ¹³ C]glutamate, [5- ¹³ C]citrate and [1- ¹³ C]acetoacetate were occasionally observed. The acetylcarnitine signal relative to octanoate tended to be lower and more variable in fasted versus fed rats. This study demonstrates that hyperpolarized ¹³ C-labeled medium-chain fatty acids can be used as metabolic probes in the heart.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.