Hyperpolarized 13 C-alpha-ketobutyrate, a pyruvate analog
Cornelius von Morze 1 , Robert A Bok 1 , Michael A Ohliger 1 , Daniel B Vigneron 1 , and John Kurhanewicz 1
Department of Radiology & Biomedical
Imaging, UCSF, San Francisco, California, United States
In this work we demonstrate hyperpolarization and rapid
in vivo enzymatic conversion of an endogenous structural
via lactate dehydrogenase (LDH). Based on prior non-MR
work and our own initial results, this hyperpolarized
probe may exhibit useful selectivity for LDHB-expressed
isoforms of LDH, such as heart or kidney LDH.
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