Free-breathing fat-water-separated liver MRI using a multi-echo 3D stack-of-stars technique
Tess Armstrong 1,2 , Isabel Dregely 1 , Fei Han 1 , Ziwu Zhou 1 , Kyung Sung 1,2 , Peng Hu 1,2 , and Holden Wu 1,2
Radiological Sciences, University of
California Los Angeles, Los Angeles, CA, United States,
Physics, University of California Los Angeles, Los
Angeles, CA, United States
Non-alcoholic fatty liver disease affects about 30% of
the general population and is the leading cause of
chronic liver disease in the United States. The gold
standard for diagnosis and monitoring is by an invasive
biopsy, which has several limitations. MRI methods based
on multi-echo fat-water separation can provide
non-invasive quantification of fat in the entire liver.
In this work, we have developed a free-breathing
multi-echo 3D stack-of-stars MRI technique that can
produce fat-water separated images of the liver with
quality comparable to a breath-held multi-echo Cartesian
technique. Our new technique has potential for
free-breathing characterization of liver fat content.
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