Abstract #0324
Dynamic imaging of hyperpolarized 6 Li cerebral distribution at pharmacological concentration
Mor Mishkovsky 1 , Andrea Capozzi 2 , Najat Salameh 2 , Jean-Noel Hyacinthe 3 , Rolf Gruetter 1,4 , and Arnaud Comment 2
1
Laboratory of Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne
(EPFL), Lausanne, Switzerland,
2
Institute
of the Physics of Biological Systems, Ecole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Switzerland,
3
Haute
Ecole de Sant, University of Applied Sciences Western
Switzerland, Geneva, Switzerland,
4
Center
of biomedical imaging (CIBM), Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Switzerland
Hyperpolarization by dissolution dynamic nuclear
polarization (DNP) allows enhancing the signal intensity
of insensitive nuclear spins such as
6
Li.
The long in vivo T
1
of
6
Li
makes it an attractive hyperpolarized contrast agent for
real-time perfusion imaging. The present study
demonstrates the feasibility of imaging in real time the
cerebral distribution of hyperpolarized
6
Li
at pharmaceutical concentration. As lithium salt is used
for treating bipolar disorder, this opens new
opportunities to assess the effect of Li
+
on
cerebral function.
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