Abstract #0337
Bias in liver fat quantification using chemical shift-encoded techniques with short echo times
Diego Hernando 1 , Utaroh Motosugi 1,2 , and Scott B. Reeder 1,3
1
Radiology, University of Wisconsin-Madison,
Madison, WI, United States,
2
Radiology,
University of Yamanashi, Yamanashi, Japan,
3
Medical
Physics, University of Wisconsin-Madison, Madison, WI,
United States
Chemical Shift Encoded (CSE) techniques for fat
quantification enable rapid and accurate quantification
of proton-density fat-fraction (PDFF), a fundamental
biomarker of triglyceride concentration in tissue.
However, these techniques suffer from relatively low SNR
due to the rapid acquisition with parallel imaging
acceleration and the use of very low flip angles. In
order to improve the SNR, acquisitions with short echo
times (eg: initial TE<1ms) and moderate spatial
resolution may be performed. In this work, we show that
these acquisitions present elevated signal at short TE,
leading to positive bias (1.6%-1.9%) in liver PDFF
relative to standard CSE or single-voxel spectroscopy.
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