Corpus Callosum Atrophy Rate in Mild Cognitive Impairment and Prodromal Alzheimers Disease
Babak Ardekani 1,2 , Sahar Elahi 1 , Alvin Bachman 1 , Sang Han Lee 1 , and John Sidtis 1,2
The Nathan S. Kline Institute for
Psychiatric Research, Orangeburg, NY, United States,
of Psychiatry, New York University School of Medicine,
New York, NY, United States
We examined temporal rates of change in CC morphology in
MCI patients to determine the differences between
converters to AD and non-converters. The spatial and
temporal patterns of CC morphological change in MCI-NC
are similar to healthy controls, while those in MCI-C
are similar to very mild/mild AD. CC atrophy is
quantifiable in a one-year longitudinal observation
period, making this a practical imaging biomarker.
Amongst the measures considered, circularity proved to
be the most sensitive measure separating convertors from
non-convertors regardless of their gender.
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