Topology of structural connectomes in healthy carriers of common gene variants associated with schizophrenia
Mark Drakesmith 1,2 , Thomas Lancaster 2 , Sonya Foley 1,2 , Lisa Brindley 1,2 , Derek K Jones 1,2 , and David Linden 1,2
CUBRIC, Cardiff University, Cardiff, Wales,
and Mental Health Research Institute, Cardiff
University, Cardiff, Wales, United Kingdom
Graph theory has been used to explore the topology of
structural connectomes in psychiatric illnesses.
However, no studies have yet looked at topology in
carriers of high-risk genotypes. Here, the effects of
two common schizophrenia-risk SNPs, ZNF804A and CACNA1C,
on network topology are examined in 85 healthy
participants. Results show differences similar to
schizophrenia in carriers of the high-risk allele of
CACNA1C and several regional deficits, including the
precuneus, a core network hub. These differences may be
due to downstream effects of synaptic dysfunction. This
study is the first to show topological network
differences in healthy carriers of high-risk genotypes.
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