Feasibility and Repeatability of Human Brown Adipose Tissue Volume and Perfusion Activity Using MRI
Weiying Dai 1 , Lauren S. Weiner 2 , David C. Alsop 1 , and Aaron M. Cypess 2
Radiology, Beth Israel Deaconess Medical
Center & Harvard Medical School, Boston, MA, United
of Integrative Physiology and Metabolism, Joslin
Diabetes Center, Boston, MA, United States
Brown adipose tissue (BAT) can improve insulin
sensitivity and hence may prove to be an important
anti-diabetic tissue. The volume and activity of BAT
have previously been measured using 18F-FDG PET/CT.
Here, we demonstrate the feasibility and repeatability
of using Dixon water/fat imaging and ASL imaging to
assess BAT volume and perfusion responses to mild cold
stimulation in the cervical area of adult humans. The
Dixon method can provide a quantitative measurement of
the BAT volume. ASL shows great promise for measuring
perfusion activity within BAT and can be successful if
the vessel signals near the BAT are well suppressed.
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