Large intramuscular vessel artifact in ASL: effect on calf muscle perfusion measurements and a velocity-selective solution
Jeff L Zhang 1 , Christopher J Hanrahan 1 , Jason Mendes 1 , Gwenael Layec 2 , Corey Hart 2 , Kristi Carlston 1 , Michelle Mueller 3 , Russell S Richardson 2 , and Vivian S Lee 1
Radiology, University of Utah, Salt Lake
City, Utah, United States,
of Geriatrics, University of Utah, Utah, United States,
Surgery, University of Utah, Utah, United States
Capable of measuring perfusion rapidly, ASL is suitable
for monitoring muscle perfusion during exercise
recovery. However, ASL estimated perfusion could be
severely erroneous for tissue voxels containing large
blood vessels. Inclusion of large-vessel voxels in a
muscle ROI could change the magnitude and the temporal
pattern of the averaged perfusion dramatically. In this
study, we studied ASL signals of blood vessel simulated
by a flow phantom, and using the obtained
velocity-perfusion relationship, developed a velocity
selective method for excluding the large-vessel voxels.
The method was shown to be effective for our healthy
subjects, and improved the perfusion accuracy.
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