Correlation of brain atrophy to decreased CBF and CVR in coronary artery disease patients.
Udunna Anazodo 1,2 , Kevin Shoemaker 3 , Neville Suskin 4 , Danny JJ Wang 5 , and Keith S St Lawrence 1,2
Lawson Health Research Institute, London,
Biophysics, Western University, London, Ontario, Canada,
of Kinesiology, Western University, London, Ontario,
Health Sciences Cardiology Rehabilitation Program,
London, Ontario, Canada,
of California, Los Angeles, California, United States
The impact of cardiovascular disease on brain structure
and function is not well known. In this study we present
evidence of cortical thinning and cerebral hypoperfusion
in brains of coronary artery disease patients including
area often associated with cognitive function.
Correlation of brain atrophy to hypoperfusion and
decreased vascular dynamics, measured with
cerebrovascular reactivity suggest that vascular disease
can accelerate decline in brain structure and function.
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