Abstract #0649
Densely packed white matter regions are less prone to develop white matter hyperintensities
Robert S Vorburger 1 , Atul Narkhede 1 , Yunglin Gazes 1 , Vanessa A Guzman 1 , Yaakov Stern 1,2 , and Adam M Brickman 1,2
1
Taub Institute, Columbia University, New
York, New York, United States,
2
Department
of Neurology, Columbia University, New York, New York,
United States
FLAIR and DTI have been widely used to investigate
cerebral white matter changes of the aging brain. The
relationship between parameters derived from the two
techniques, such as white matter hyperintensities (WMH)
and fractional anisotropy (FA), is still poorly
understood. To investigate this relationship, a
reference FA map from a sample of young subjects and a
WMH probability map from a sample of elderly subjects
was computed. Regions with a high FA value in the young
brain show a significant lower WMH probability in the
elderly brain, indicating that densely packed fiber
tracts are less prone to develop WMH.
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