Black-Blood Contrast-Enhanced MRI: Validation of a Novel Technique for the Diagnosis of Myocardial Infarction
Han W Kim 1 , Wolfgang G Rehwald 2 , David C Wendell 1 , Elizabeth R Jenista 1 , Lowie Van Assche 1 , Christoph Jensen 1 , Peter Filev 1 , Enn-Ling Chen 1 , Michele A Parker 1 , and Raymond J Kim 1
Cardiology/Medicine, Duke Cardiovascular
Magnetic Resonance Center, Duke University Medical
Center, Durham, NC, United States,
Healthcare, NC, United States
PURPOSE. Flow-Independent Dark-blood DeLayed-Enhancement
(FIDDLE) allows visualization of tissue
contrast-enhancement with blood-pool suppression.
METHODS. We validated FIDDLE in a canine model of
myocardial infarction (MI) and demonstrated feasibility
in patients. FIDDLE and standard delayed-enhancement-MRI
(DE-MRI) were compared to histopathology (animals) and
the infarct-related-artery by cath (patients). RESULTS.
FIDDLE black-blood images were successfully obtained in
all animals and patients, and provided improved accuracy
for the diagnosis of MI compared with DE-MRI.
CONCLUSIONS. We have developed a novel technique that
provides tissue contrast-enhancement simultaneous with
blood-suppression. Validation and feasibility is
demonstrated for diagnosis of MI; additional
applications are expected beyond cardiac imaging.
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