Abstract #0668
Impact of Non-rigid Motion Correction on Pharmaco-kinetic Analysis for Breast Dynamic Contrast-Enhanced MRI
Venkata Veerendra Nadh Chebrolu 1 , Dattesh Shanbhag 1 , Reem Bedair 2 , Sandeep Gupta 3 , Patrice Hervo 4 , Scott Reid 5 , Fiona Gilbert 2 , Andrew Patterson 6 , Martin Graves 7 , and Rakesh Mullick 8
1
Medical Image Analysis Lab, GE Global
Research, Bangalore, Karnataka, India,
2
Radiology,
University of Cambridge, Cambridge, United Kingdom,
3
Biomedical
Image Analysis Lab, GE Global Research, NY, United
States,
4
GE
Healthcare, Buc, France,
5
GE
Healthcare, Amersham, United Kingdom,
6
Cambridge
University Hospitals Trust, Cambridge, United Kingdom,
7
Radiology,
Cambridge University Hospitals Trust, Cambridge, United
Kingdom,
8
Diagnostics & Biomedical
Technologies, GE Global Research, Bangalore, Karnataka,
India
Dynamic contrast-enhanced (DCE)-MRI is increasingly
being used in understanding the pharmaco-kinetic (pK)
characteristics of breast tumors. The Ktrans and ve
estimates used in tumor characterization depend on the
DCE concentration time courses. Cardiac pulsation,
breathing and voluntary patient motion introduce rigid
and non-rigid motion, which may corrupt the DCE
analysis. Previous work demonstrated symmetric
diffeomorphic normalization (SyN) to be more effective
than b-splines based approaches in correcting for motion
in breast DCE MRI. In this work we demonstrate the
impact of SyN based non-rigid registration on pK
modelling for breast DCE-MRI.
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