Electroconvulsive Therapy (ECT) induced neurochemical modulation as measured by 1 HMRS in Major Depression
Shantanu H Joshi 1 , Stephanie Njau 1 , Amber Leaver 1 , Antonio Marquina 2 , Roger P Woods 1 , Randall Espinoza 3 , and Katherine L Narr 1
Neurology, UCLA, Los Angeles, CA, United
University of Valencia, Valencia, Spain,
and Behavioral Sciences, UCLA, Los Angeles, CA, United
Proton magnetic resonance spectroscopy (1HMRS) offers a
non-invasive technique for measuring the neurochemical
disturbances in cortico-limbic regulatory circuits in
depression. Electroconvulsive therapy (ECT) is a rapidly
acting treatment for patients with severe depression.
While patients with major depression show abnormal
neurochemistry, several emerging hypotheses for ECT
induced neuroplasticity have led to measuring the ECT
driven neuro-metabolite response using 1HMRS. Here, we
examined cross-sectional and longitudinal ECT treatment
effects on glutamate/glutamine (Glx), N-acetyl aspartate
(NAA), creatinine+phospocreatinie (Cr/PCr), and
myo-inositol (mI) in the hippocampus, and the dorsal and
subgenual cingulate in patients with major depressive
disorder (MDD) along with cross-sectional diagnosis
effects in metabolites when compared to age and gender
matched healthy controls.
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