Age-Related Changes of Aortic Hemodynamics Derived from 4D flow MRI in 60 Healthy Volunteers
Pim van Ooij 1,2 , Julio Garcia 2 , Susanne Schnell 2 , Jeremy D Collins 2 , James C Carr 2 , Michael Markl 2,3 , and Alex J Barker 2
Radiology, Academic Medical Center,
Northwestern University, Chicago, IL, United States,
Engineering, Northwestern University, Chicago, IL,
Age-related changes in 4D flow MRI derived peak/mean
velocity, Wall Shear Stress (WSS), velocity Time To Peak
(TTP) and Mid-Ascending Aortic diameter (MAA) were
investigated in 60 healthy volunteers (19-79 years old).
A significant increase in peak velocity
(R=0.39,P=0.001), decrease in mean velocity (R=0.53,
P<0.001), WSS (R=0.59, P<0.001), TTP (R=0.39, P=0.001)
and MAA (R=0.57, P=<0.001) was found with increasing
age. The results show the importance of matching patient
age to the appropriate control group.
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