Evidence of Early Left Ventricular Dysfunction in Bicuspid Aortic Valve Patients Identified by MRI-Based Wave Intensity Analysis
Nicholas Scott Burris 1 , Petter Dyverfeldt 2 , and Michael D Hope 1
Radiology, University of California San
Francisco, San Francisco, CA, United States,
for Medical Image Science and Visualization, Linkping
University, Linkping, Sweden
Bicuspid aortic valve (BAV) is a common congenital
cardiac abnormality associated with abnormal aortic
flow, increased aortic stiffness and valvular
dysfunction, which may predispose to abnormal
ventricular-arterial coupling. Wave intensity analysis
(WIA) was used to measure a maker left ventricular
function, forward compression wave (FCW), using 2D
phase-contrast MRI. We found decreased average FCW
values in BAV patients compared to normal patients.
Amongst BAV patients, two features of BAV-aortopathy
(aortic stiffness and aortic diameter) were found to
predict decreases in FCW. WIA may identify early and
adverse changes in ventricular-arterial coupling in
patients with BAV that would otherwise go unnoticed.
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