Abstract #0999
A new MT signal at -1.6 ppm via NOE-mediated saturation transfer
Xiao-Yong Zhang 1 , Hua Li 1 , Junzhong Xu 1 , Jingping Xie 1 , John C. Gore 1 , and Zhongliang Zu 1
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
Magnetization transfer (MT) provides a unique mechanism
for producing contrast and makes MRI sensitive to the
presence of metabolites, mobile macromolecules, and
semisolid macromolecules through their magnetic
coupling effects on the water signal. Although the
nuclear Overhauser enhancement (NOE)-mediated MT signal
at -3.5 ppm has been recently studied, to date no in
vivo MT effect at -1.6 ppm has been reported. We report
a new MT signal MT at -1.6 ppm, which may reflect the
NOE effect between choline headgroup of membrane
phospholipids and water protons. The MT signal at -1.6
ppm could be used as a new biomarker in healthy rat
brain.
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