Abstract #1094
Multimodal Imaging of a Mouse Model of Colorectal Carcinoma Metastasis in the Liver
Rajiv Ramasawmy 1,2 , Sean Peter Johnson 1,2 , Thomas Anthony Roberts 1 , Daniel J Stuckey 1 , Anna L David 3 , Rosamund Barbara Pedley 2 , Mark Francis Lythgoe 1 , Bernard Siow 1 , and Simon Walker-Samuel 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
United Kingdom,
2
Cancer
Institute, University College London, London, Greater
London, United Kingdom,
3
Institute
for Women's Health, University College London, London,
Greater London, United Kingdom
Orthotopic tumor models are thought to provide a more
clinically-representative model of disease than
traditional subcutaneous implantations, although their
siting often renders them more difficult to assess. In
this study, we compared 1T benchtop MRI and ultrasound
with our gold-standard techniques of bioluminescence
imaging (for cell detection) and 9.4T MRI (for tumour
volume assessment) in their ability to characterise the
development of liver metastases over four weeks. No
significant differences were observed in the measured
tumour doubling, showing that each of these techniques
can be used for characterising tumour growth in
deep-sited tumours, although each has characteristic
advantages and disadvantages.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
