Abstract #1095
In Vivo Magnetic Resonance Elastography in Pediatric Brain Tumor Models
Jessica K.R. Boult 1 , Jin Li 1 , Yann Jamin 1 , Maria Vinci 2,3 , Sergey Popov 2,3 , Karen Barker 4 , Zai Ahmad 4 , Craig Cummings 1 , Suzanne A Eccles 3 , Jeffrey C Bamber 1 , Ralph Sinkus 5 , Louis Chesler 4 , Chris Jones 2,3 , and Simon P Robinson 1
1
Division of Radiotherapy and Imaging, The
Institute of Cancer Research, London, United Kingdom,
2
Division
of Molecular Pathology, The Institute of Cancer
Research, London, United Kingdom,
3
CR-UK
Division of Cancer Therapeutics, The Institute of Cancer
Research, London, United Kingdom,
4
Division
of Clinical Studies, The Institute of Cancer Research,
London, United Kingdom,
5
Division
of Imaging Sciences & Biomedical Engineering, Kings
College London, London, United Kingdom
Refined imaging strategies that could improve diagnosis
and management of children with brain malignancies are
urgently required. MR elastography (MRE) has been used
to assess viscoelastic properties in the brain and brain
tumors clinically and preclinically. We evaluated
orthotopic D-212 MG pediatric glioblastoma xenografts
and GTML/Trp53
KI/KI
transgenic
medulloblastomas using MRE. Both tumor types
demonstrated reduced elasticity (G
d
) and
viscosity (G
l
) relative to the surrounding
brain. A bimodal distribution of G
d
, not seen
previously, was observed in GTML/Trp53
KI/KI
tumors.
These data reinforce the potential of MRE for the
detection and differential diagnosis of pediatric brain
malignancies based on their mechanical properties.
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