Abstract #1129
Amine as a novel biomarker for differentiating malignancy of breast cancer cells
Xiao-Yong Zhang 1 , Jingping Xie 1 , Hua Li 1 , Junzhong Xu 1 , John C. Gore 1 , and Zhongliang Zu 1
1
Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States
To differentiate the malignancy of breast cancer cells
is vital for optimal cancer treatment. Amide proton
transfer (APT), a chemical exchange saturation transfer
(CEST) technique, has been reported to show changes in
brain tumors, but amine proton exchange from endogenous
metabolites and free proteins/peptides side chains can
also be a major contributor to CEST signal. In this
work, we show how differences in amine proton exchange
may be used to differentiate breast cancer cells with
different malignant potential and conclude that amine
proton may function as a new endogenous biomarker for
non-invasively evaluating malignancy of breast cancer
cells.
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