Quantitative DCE Analysis for Breast Imaging: The Benefit of Dixon Fat-Water Separation in an ultrafast TWIST-VIBE Protocol
Elisabeth Weiland 1 , Sandra Peter 2 , Dominik Nickel 1 , Rolf Janka 2 , Michael Uder 2 , and Evelyn Wenkel 2
MR Application Developement, Siemens
Healthcare, Erlangen, Germany,
University of Erlangen, Germany
We evaluated the potential of Dixon fat-water separation
using an ultrafast view sharing DCE protocol to
differentiate between benign and malignant lesions of
very early contrast phases. Analysis of maximum slope
(MS) and time-to-enhancement (TTE) of the kinetic curves
were performed on water-only images for 37 mass lesions.
Best differentiation was achieved with MS, derived from
the water-only images (ROC analysis with area under
curve of 0.914). Due to its short acquisition time and
its robust image quality ultrafast dual-echo sequences
with Dixon fat-water separation may be beneficial for
MR-based breast screening.
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