Alterations to breast tissue chemistry in women at risk of cancer: 2D MR spectroscopy in vivo study
Jessica Buck 1 , Saadallah Ramadan 1 , Leah Best 2 , Judith Silcock 3 , Jameen Arm 2 , Scott Quadrelli 1 , Gorane Santamaria 1 , Kin Men Leong 2 , Peter Lau 2 , Peter Malycha 1 , David Clark 1,3 , and Carolyn Mountford 1,4
Centre for MR in Health, University of
Newcastle, Newcastle, NSW, Australia,
Mater Hospital, Newcastle, NSW, Australia,
Breast and Endocrine Centre, Gateshead, NSW, Australia,
for Clinical Spectroscopy, Department of Radiology,
Brigham and Women's Hospital, Harvard Medical School,
Boston, MA, United States
In vivo 2D L-COSY identifies premalignant changes in
women at high risk of developing breast cancer that are
not seen by routine imaging, and allows women to be
identified as MR spectroscopy Low Risk or MR
spectroscopy High Risk according to changes recorded.
Changes in the MR spectroscopy High Risk group include
deregulation of lipid pathways and increased levels of
metabolites. If these changes are confirmed in larger
populations, it is possible that this information will
allow women at increased clinical risk for breast cancer
an objective means to monitor changes that may be taking
place in their breast tissue.
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