Quantifying Muscle Inflammation with Diffusion Basis Spectrum Imaging
Carlos J Perez-Torres 1 , Neva B Watson 2 , Yong Wang 1,3 , Paul T Massa 2,4 , and Sheng-Kwei Song 1,3
Radiology, Washington University, St. Louis,
MO, United States,
& Immunology, SUNY Upstate Medical University, Syracuse,
NY, United States,
Center for Neurological Disorders, Washington
University, St. Louis, MO, United States,
SUNY Upstate Medical University, Syracuse, NY, United
Once considered a tropical disease, infectious myositis
is an underappreciated emerging global affliction.
Diffusion basis spectrum imaging (DBSI) has been
previously utilized to separately quantify inflammatory
pathology and fiber pathology in white matter diseases
such as multiple sclerosis. The present work is the
first example of DBSI being applied to muscle pathology.
DBSI-derived restricted isotropic diffusion is usually
associated with increased immune cell infiltration. The
restricted fraction increased in both lesion and
normal-appearing muscle. At first glance, DBSI seems
capable of detecting inflammation in the muscle that
might be missed by just looking at ADC or FA.
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