Abstract #1372
Improve lateralizing sensitivity in temporal lobe epilepsy by combining structural MRI with regional cerebral blood flow and apparent diffusion coefficient
Xiaoqin GUO 1,2 , Shangchen XU 3 , Guangbin WANG 1 , Yi ZHANG 4 , Lingfei GUO 1 , and Bin ZHAO 1
1
MRI, Shandong Medical Imaging Research
Institution, Jinan, Shandong, China,
2
Medicine,
Shandong University, Jinan, Shandong, China,
3
Neurosurgery,
Shandong Provincial Hospital, Shandong, China,
4
Medical
Imaging Processing Center, Shandong Medical Imaging
Research Institution, Shandong, China
Structural MRI contributes a lot in the lateralization
of temporal lobe epilepsy (TLE) with mesial temporal
sclerosis (MTS), especially FLAIR sequence. However, 1/3
TLE patients appear normal on structural MRI. MRI
perfusion and DWI have been reported helpful for
lateralization of non-MTS TLE patients. Our study aims
to explore their performance of lateralization in TLE
using ASL and DWI techniques by calculating asymmetry
indices of regional cerebral blood flow (CBF) and
apparent diffusion coefficient (ADC) values. The
sensitivity/specificity of lateralization in TLE is
55.6%/100% by only FLAIR images, and can reach to
85.2%/100% and 70.4% /100% by adding asymmetry indices
of CBF and ADC values as covariates for ROC curves
respectively. We concluded that ASL and DWI can help for
lateralization in TLE and ASL is better.
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