Abstract #1378
MR spectroscopic studies of early post status epilepticus in rats
Yijen Lin Wu 1,2 , Patrice Pearce 1 , Amedeo Rapuano 3 , T. Kevin Hitchens 4 , Nihal deLanerolle 3 , and Jullie W Pan 1,5
1
Neurology, University of Pittsburgh,
Pittsburgh, PA, United States,
2
Developmental
Biology, University of Pittsburgh, Pittsburgh, PA,
United States,
3
Neurosurgery,
Yale University, New Haven, CT, United States,
4
Pittsburgh
NMR Center for Biomedical Research, Carnegie Mellon
University, Pittsburgh, PA, United States,
5
Radiology,
University of Pittsburgh, Pittsburgh, PA, United States
The development of spontaneous recurrent seizures
(epilepsy) is a complex process that commonly ensues
after an initial cerebral insult. We used MR
spectroscopy and T2 relaxometry in a rodent model to
understand how moderate variability in status
epilepticus influences such metabolic injury in early
epileptogenesis. The nature of the injury can be
considered to be classified as neuronal, glial or joint
pathophysiological processes. The MR spectroscopic and
imaging can be informative towards individual
identification of injury severity and may enable
identification of a MR based biomarker to predict the
development of epilepsy.
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