Abstract #1391
Central sulcus and pericentral cortical changes in multiple sclerosis
Louise Pape 1 , Artem Mikheev 1 , Jeffrey Huang 1 , Joseph Herbert 1 , Henry Rusinek 1 , and Yulin Ge 1
1
Radiology/Center for Biomedical Imaging, NYU
Langone Medical Center, New York, NY, United States
Cortical atrophy is a key imaging hallmark of multiple
sclerosis (MS). The aim of this study was to investigate
the differences in sulcal volume, width and depth of the
central sulcus as well as pericentral cortical gray
matter (Pc-CGM) thickness between MS patients and
healthy controls. Results showed increased volume and
width of the central sulcus and decreased Pc-CGM in
patients. The sulcal changes correlated with the local
atrophy measure of Pc-CGM in patients. Since CS metrics
are correlated with clinical disability measure, there
is potential to use them as quantitative markers of
progression.
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