Validating a power relationship between cerebral blood volume and cerebral blood flow

Cerebral blood volume (CBV) is related with cerebral blood flow (CBF), and knowing this relationship may play an important role in quantitative BOLD-fMRI studies. A recent MRI study reports a sex-dependent CBV-CBF power relationship in the human visual cortex. In this study, we computed CBV for each CBF using the power function and the CBF values at both rest and activation states. Comparisons of these computed CBV values with their corresponding measured CBV values for each sex revealed significant differences (max P=0.0014), suggesting the CBV-CBF relationship may not be best characterized by the power function.

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