Abstract #1442
Mapping Human Cerebral Vascular/Metabolic Activity Coupling at High-Resolution
William D. Rooney 1,2 , Xin Li 1 , Dennis N. Bourdette 3 , and Charles S. Springer, Jr. 1,2
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Knight
Cardiovascular Institute, Oregon Health & Science
University, Portland, Oregon, United States,
3
Department
of Neurology, Oregon Health & Science University,
Portland, Oregon, United States
The unidirectional rate constant for
equilibrium
capillary
water efflux, k
po
, has been mapped with high
resolution in the normal and normal-appearing MS human
brain. It is the reciprocal of the mean capillary water
molecule lifetime. The rate constant k
po
is
greater in white matter than in gray matter. Comparison
with literature spectroscopic imaging of metabolites and
metabolic fluxes shows that k
po
tracks
the oxidative phosphorylation flux per capillary. The k
po
quantity
detects whole-brain compromise in early stage MS.
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