Abstract #1445
Quantification of perfusion and xenon-transport across the blood-brain barrier in humans with hyperpolarized 129 Xe brain MR at 1.5T
Madhwesha Rao 1 , Neil Stewart 1 , Graham Norquay 1 , and Jim Wild 1
1
University of Sheffield, Sheffield, South
Yorkshire, United Kingdom
When inhaled into the lungs, xenon dissolves in blood,
and is carried to the brain via the systemic
circulation, where it, crosses the blood-brain barrier
and dissolves into brain tissue. 129Xe has large
chemical shift providing contrast for cerebral blood,
grey-matter, white-matter and lipid. In this work, using
hyperpolarized xenon we measure the transfer rate of
xenon from cerebral blood to brain tissue across the
blood-brain barrier. The transit response of the
blood-brain barrier is demonstrated and proposed as a
physiological indication of intrinsic permeability to
xenon.
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