Correlation of Lesion Size to Thermal Dose Measured by MR Thermometry in MR-Guided Focused Ultrasound for the Treatment of Essential Tremor
Yuexi Huang 1 , Nir Lipsman 2 , Michael L. Schwartz 3 , Vibhor Krishna 2 , Francesco Sammartino 2 , Andres M. Lozano 2 , and Kullervo Hynynen 1,4
Sunnybrook Research Institute, Toronto, ON,
of Neurosurgery, Toronto Western Hospital, Toronto, ON,
of Neurosurgery, Sunnybrook Health Sciences Centre,
Toronto, ON, Canada,
of Medical Biophysics, University of Toronto, Toronto,
Magnetic resonance guided focused ultrasound has shown
promising results in the treatment of essential tremor.
MR temperature and thermal dose measurement plays a
crucial role in monitoring and guiding acoustic
parameters. In general, the size of the lesion can be
detected by MR imaging immediately after the treatment
is significantly smaller than the size on the following
day while the lesion continues to develop over hours.
Therefore, it would be useful if thermal dose can be
used to predict the ultimate lesion size and thus
determine the end point of the treatment. In this study,
we correlated the size of the thermal dose to the lesion
size at the follow-up imaging on the second day and
found the lesion sizes were between 240 and 17 EM
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