Ferumoxytol-enhanced Plural Contrast Imaging of the Human Brain
Samantha J Holdsworth 1 , Thomas Christen 1 , Kristen Yeom 1 , Jae Mo Park 1 , Greg Zaharchuk 1 , and Michael E Moseley 1
Department of Radiology, Stanford
University, Stanford, CA, United States
In the present study, we generate multiple contrast
mechanisms following the injection of Ferumoxytol (an
FDA-approved ultra-small paramagnetic iron oxide [USPIO]
compound) in the pediatric brain. The high magnetic
susceptibility of ferumoxytol and its long halflife
allows the acquisition of high quality/high spatial
resolution 3D ME-GRE images in only 5:44-minutes and
subsequent generation of R2* maps, field maps,
Susceptibility-Weighted Imaging (SWI), Time-of-Flight
(TOF), and Quantitative Susceptibility Maps (QSM).
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