Abstract #1750
Eliminating MT Contribution in Z-Spectra using Dual Band Macromolecular Background Suppression (DBMS)
Simon Shah 1 , Nicolas Geades 1 , Andrew Peters 1 , Penny Gowland 1 , and Olivier Mougin 1
1
Sir Peter Mansfield Imaging Centre, School
of Physics and Astronomy, University of Nottingham,
Nottingham, Nottinghamshire, United Kingdom
Chemical Exchange Saturation Transfer (CEST) and Nuclear
Overhauser Enhancement (NOE) effects have the potential
to transform MRI into a molecular imaging technique.
Dual band macromolecular background suppression (DBMS)
pulses are designed to saturate two RF frequencies
simultaneously. One of the frequency bands provides
suppression of the macromolecular contribution across
the whole z-spectrum whilst the other sweeps the
Z-spectrum. DBMS provides a method to uncouple MT
effects from other features of the z-spectrum which will
simplify quantification and separation of different
z-spectrum features.
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